منابع مشابه
REVIEW —Current Perspective— Brain Drug Targeting and Gene Technologies
Brain drug targeting technology is based on the application of four gene technologies that enable the delivery of drugs or genes across the blood-brain barrier (BBB) in vivo. I) Genetic engineering is used to produce humanized monoclonal antibodies that target endogenous BBB transporters and act as vectors for delivery of drugs or genes to the human brain. The conjugate of a neurotherapeutic an...
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Recent progress in the development of molecular genetic methods enables the manipulation of genes in intact mammalian organisms. The power of such techniques to elucidate complex biological systems was initially recognized and exploited by developmental biologists and immunologists. More recently, the utility of these approaches for examining neural gene function in the context of the intact or...
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Many brain diseases (such as meningitis, encephalitis, multiple sclerosis (MS), stroke, brain tumors, epilepsy, Alzheimer's disease, AIDS related dementia, Parkinson's disease) are under treated or cannot be treated at all due to the presence of the barriers in the brain (blood-brain barrier, blood-cerebrospinal fluid barrier and the braincerebrospinal fluid barrier). The blood-brain barrier is...
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INTRODUCTION Ocular targeted therapy has enormously been advanced by implementation of new methods of drug delivery and targeting using implantable drug delivery systems (DDSs) or devices (DDDs), stimuli-responsive advanced biomaterials, multimodal nanomedicines, cell therapy modalities and medical bioMEMs. These technologies tackle several ocular diseases such as inflammation-based diseases (e...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2001
ISSN: 0021-5198
DOI: 10.1254/jjp.87.97